All-electronic high-throughput analyte detection system

A detection system comprising:

• a platform configured to receive a sample holder comprising a plurality of sample wells;
• and
• a plurality of sensing modules coupled to the platform, wherein a sensing module of the plurality of sensing modules comprising:
• a sensor coupled to the platform;
• and
• a first electrode coupled to the platform, the first electrode configured to electrically connect with the sensor via a feedback circuit,
• wherein the feedback circuit is configured to provide a feedback signal via the first electrode to a sample received in a sample well of the plurality of sample wells, the feedback signal based on a potential of the received sample detected via a second electrode.

A method of detecting analytes comprising:

• detecting a potential associated with a sample received in a sample well by a first electrode;
• generating a feedback signal by a feedback circuit electrically coupled to the first electrode;
• and
• providing the feedback signal to the sample via a second electrode, the feedback signal configured to provide excitation control of redox species in the sample at a third electrode,
• wherein the first, the second and the third electrodes are coupled to a platform configured to receive the sample well.