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US 2019/0152909 A1Published application
Processes to produce brivaracetam
AssigneeESTEVE QUIMlCA S.A.
InventorsPeng WANG, Pixu LI, Qiang WEI, Yuanhua LIU
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Abstract
The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.
Claims12
A process of making the compound of formula XII (brivaracetam) from the compound of formula X
A process for the preparation of brivaracetam, comprising the ring-closing reaction as follows:
- in the presence of a base, wherein R is NH2, C1-C20 alkoxyl;
- X is Cl, Br, I, OMs, OTs, or ONs;
- if R is NH2 and X is Cl then XI-b is XI, and if R is NH2 XII-a is XII.
A process for the preparation of the compound of formula X from the compound of formula VI
A process for preparation of the compound of formula XII (brivaracetam), which comprises the steps of:
A process for preparation of the compound of formula XII (brivaracetam), which comprises the steps of:
Dependencies are inferred from the claim text.