Topical Compositions, Process of Manufacture and Method of Use

A method of combining hydrophobic components and hydrophilic components with high dosage of active ingredients, comprising the steps of:

• a) placing hydrophobic components that are a liquid or become a liquid at 40° C. to 50° C. in a first vessel and placing hydrophilic components that are a liquid or become a liquid at 40° C. to 50° C. in a second vessel;
• b) inserting into each of the first vessel and the second vessel a propeller mixer rotating at 300 to 500 rotations per minute (RPM) propeller mixing speed and heating each of the first vessel and the second vessel to 40° C. to 50° C.;
• c) after sufficient mixing at 40° C. to 50° C., placing hydrophobic components that are not liquid at 40° C. to 50° C. in the first vessel and placing hydrophilic components that are not liquid at 40° C. to 50° C. in the second vessel, and increasing rotation of each propeller mixer to 700 to 900 RPM and increasing the temperature of the first vessel and the second vessel to 60° C. to 80° C.;
• d) after sufficient time for mixing and completion of reaction in the first vessel and the second vessel, pouring the contents of the second vessel into the first vessel and combining the contents of both vessels, and maintaining the rotation of the propeller mixer at 700 to 900 RPM and temperature at 60° C. to 80° C. for an additional 10-40 minutes of reaction time;
• e) adjusting pH to 7.5 with NaOH;
• f) cooling the mixed contents in the first vessel slowly over several hours to ambient temperature by insulating the first vessel and reducing the propeller mixer to 500-700 RPM;
• g) stopping the propeller mixer after the contents in the first vessel reaches ambient temperature;
• h) filling mixed content into a container.