Biomarkers for resistance to porcine circovirus 2 associated disease
AssigneeBoard of Regents of the University of Nebraska
InventorsDaniel Constantin Ciobanu, Lianna Rayne Walker, Taylor Benjamin Engle, Hiep Vu
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Abstract
The present disclosure provides compositions and methods for increasing resistance to PCV2 infection in pigs. The increased resistance may be the result of siRNA or genetic modification through CRISPR or a vectored virus targeting SNPs that are resistant to PCV2 infection.
Claims8
A method of increasing resistance to PCV2 infection in an animal comprising the step of genetically modifying said animal such that it includes nucleic acid sequences encoding for SYNGR2 p.Arg63Cys, wherein resistance is determined by a comparison of the severity and/or incidence of clinical signs of PCV2 infection or PCVAD in animals that have been genetically modified with animals that have not been genetically modified.
A genetically modified animal wherein said genetically modified animal has nucleic acid sequences encoding for SYNGR2 p.Arg63Cys inserted into the genome of said animal.
A composition for reducing the incidence and or severity of clinical signs of PCV2 infection or PCVAD comprising a pharmaceutically-acceptable carrier together with siRNA that blocks p.Arg63Arg.
Dependencies are inferred from the claim text.