Method for coupling a first compound to a second compound

A method for coupling a first compound A1 a second compound A2, as illustrated in Equation 1, comprising:

• providing the first compound A1 having a hydroxyl substituent, sulfuryl fluoride and a base to a reaction mixture, the first compound A1 comprising an aryl group or a heteroaryl group, the base comprising a carbonate salt, a phosphate salt or an acetate salt;
• providing a catalyst comprising a group 10 atom and the second compound A2 to the reaction mixture, the second compound A2 as defined in Equation 4:
• the second compound A2 comprising an amine wherein each of R1 and R2 are independently Hydrogen, an aryl group, a heteroaryl group, an alkyl group, a cycloalkyl group, a nitro group, a halide, a nitrogen, a cyano group, a carboxyester group, an acetoxy group, a substituted alkyl, aryl, heteroaryl or cycloalkyl group, or R1 and R2 are constituent parts of a ring system;
• reacting the first compound and the second compound under conditions effective to couple the first compound to the second compound.