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US 2019/0071720 A1Published application
Devices, systems and methods for nucleic acid sequencing
AssigneeQuantum Biosystems Inc.
InventorsEric S. Nordman, Mark Oldham, Takeshi Akatsu
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Abstract
The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. A sequence of a nucleic acid molecule may be identified at high accuracy using a chip comprising an array of sensors, wherein each individual sensor comprises at least one nano-gap electrode pair configured to generate electrical signals upon flow of the nucleic acid molecule through or in proximity to at least one nano-gap of the nano-gap electrode pair.
Claims22
-113. (canceled)
A method for sensing a sample molecule using a nano-gap sensor, comprising:
- (a) providing a chip comprising said nano-gap sensor, said nano-gap sensor comprising a nano-gap comprising one or more nano-gap electrode pairs that are adapted to generate signals upon flow of electrical current across said nano-gap;
- (b) flowing said sample molecule or portion thereof through or in proximity to said nano-gap, wherein said sample molecule comprises a plurality of monomers comprising labels that permit individual monomers of said plurality of monomers to be identified from one another upon flow of said sample molecule or portion thereof through or in proximity to said nano-gap;
- (c) using said one or more electrode pairs to detect said signals or changes thereof based at least in part on said labels while said sample molecule or portion thereof flows through or in proximity to said nano-gap;
- and
- (d) using said signals or changes thereof to identify said individual monomers, thereby determining a sequence of said sample molecule or portion thereof.
2 more elements
Dependencies are inferred from the claim text.