Method for detecting imminent childbirth
AssigneeBiosynex
InventorsThierry PAPER, Capucine BLIN
Life of this patent
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Abstract
Some embodiments are directed to a method for the in vitro detection/prediction of imminent childbirth based on the detection of at least two of the following markers: insulin-like growth factor-binding protein 1 (IGFBP-1), an N-terminal fragment of insulin-like growth factor-binding protein 1, and interleukin 6 (IL-6). Some embodiments are also directed to a device for the implementation of the method. Some embodiments are applicable in the medical field, in the diagnostic field, and in particular in the obstetric field.
Claims21
A method for the in vitro detection/prediction of an imminent birth, comprising:
- simultaneously searching, in a specimen of vaginal or cervical secretions, for markers of a group consisting of intact insulin-like growth factor binding protein 1 (IGFBP-1 A), of intact insulin-like growth factor binding protein 1 and/or an N-terminal fragment of insulin-like growth factor binding protein 1 (IGFBP-1 B) and of interleukin 6 (IL-6);
- and
- detecting or predicting an imminent birth if at least two of the markers of the group consisting of insulin-like growth factor binding protein 1 A (IGFBP-1 A), of insulin-like growth factor binding protein 1 B (IGFBP-1 B) and of interleukin 6 (IL-6), are detected.
A method for the in vitro detection/prediction of an imminent birth in a sample of vaginal or cervical secretions, comprising:
- a) searching for the presence of IGFBP-1 A, of IGFBP-1 B and of IL-6,
- b) assigning a value of IGFBP-1 A (IA) if IGFBP-1 A is present in the sample or of 0 if IGFBP-1 A is not present,
- c) assigning a value of IGFBP-1 B (IB) if IGFBP-1 B is present in the sample or of 0 if IGFBP-1 B is not present, the value of IB assigned if IGFBP-1 B is present in the sample being less than or equal to the value of IA assigned when IGFBP-1 A is present in the sample,
- d) assigning a value of IL-6 (I6) if IL-6 is present in the sample or of 0 if IL-6 is not present, the value I6 assigned when IL-6 is present in the sample being strictly less than the values of IA and IB assigned when IGFBP-1 A and IGFBP-1 B are respectively present in the sample,
- e) calculating the score S1 according to the following formula:
- S1=IA+IB+I6
- a value of S1 greater than or equal to the value of IA or IB, respectively assigned when IGFBP-1 A or IGFBP-1 B is present in the sample, indicating an imminent birth.
(canceled)
Dependencies are inferred from the claim text.