Modulating epigenetic dna methylation to cause cells to adopt dna methylation patterns associated with young cells

A composition comprising:

• (a) an Oryza sativa meristem undifferentiated cell suspension extract, wherein said extract is derived from said Oryza sativa meristem, said extract comprising at least one secondary metabolite, selected from the group of secondary metabolites consisting of flavonoids, carotenoids, protease-inhibitors, phytic acids, alkaloids, terpenoids, glycosides, phenols, polyketides, and polyphenols;
• wherein said secondary metabolite is water soluble;
• and
• (b) a preservative present in an amount sufficient to provide sterilizing and biostatic efficacy with respect to component (a),
• wherein component (a) is present in an amount of 90 percent to 99 percent by weight of the composition, and component (b) is present in an amount of 0.5 percent to 1 percent by weight of the composition.

A topical composition comprising:

• (a) a rice plant meristem cell suspension extract, wherein said extract is derived from said rice plant meristem. said extract comprising at least one secondary metabolite, selected from the group of secondary metabolites consisting of flavonoids, protease-inhibitors, phytic acids, alkaloids, terpenoids, glycosides, phenols, polyketides, and polyphenols;
• wherein said secondary metabolite is water soluble;
• wherein said extract is prepared by a process comprising the steps of:
• (i) providing totipotent, undifferentiated rice plant cells derived from rice plants of Oryza sativa;
• (ii) growing the rice plant cells in a liquid nutrient media in the presence of ozone to elicit expression of secondary plant cell metabolites to produce a mixture containing water-soluble and water-insoluble components;
• and
• (iii) removing the water insoluble components;
• (b) a preservative present in an amount sufficient to provide sterilizing or biostatic efficacy with respect to component (a), wherein the preservative is selected from the group consisting of salicylic acid, sorbic acid, phenoxyethanol, benzyl alcohol, ethanol, quaternium-15, glucose oxidase and lactoperoxidase in combination with a substrate, and combinations thereof;
• and
• (c) a dermatologically acceptable vehicle;
• wherein component (a) is present in an amount of 0.001 percent to 25 percent by weight of the composition, component (b) is present in an amount of 0.5 percent to 1 percent by weight of the composition, and component (c) is present in an amount of 1 percent to 98 percent by weight of the composition.