Mri and ct contrast-enabled composite implants for image-guided tissue regeneration and therapy

A composite implant comprising a scaffold or beads for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast, comprising:

• a calcium compound in the form of nano- or micro-particle comprising a first dopant and a second dopant, wherein the first dopant is configured to provide MRI contrast and the second dopant is configured to provide CT contrast;
• and
• a biopolymer matrix comprising a polymer, wherein the polymer comprises alginate, gelatin, collagen, chitosan, carboxymethyl chitosan, chitin, cellulose, carboxymethyl cellulose, dextran, fibrin, hyaluronic acid, chondroitin sulphate, agarose, starch, poly[lactic-co-glycolic] acid, poly-L-lactic acid, polylactic acid, polycaprolactone, polyvinyl alcohol, polyhydroxy butyrate, polyhydroxy butyrate co hydroxyvalerate, polyphosphazenes, polyurathane, or polyanhydrides;
• wherein the scaffold or beads comprise 3-dimensional interconnected porosity.