Pharmaceutical composition for cancer treatment, process for its preparation, and its use
AssigneeSpinomics Ltda. - EPP
InventorsRicardo Amaral Remer, Rogério Margis, Ana Paula Christoff
Life of this patent
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Abstract
The use of the C-terminal region of one or more phytocystatin(s) for the curative or prophylactic treatment of tumors and/or inhibition of metastases in mammals or other vertebrates. In one embodiment, the pharmaceutical composition of the invention comprises a pharmaceutically acceptable carrier and a polypeptide containing only the C-terminal region of one or more phytocystatin(s). In another embodiment, the composition of the invention comprises a gene construct for the in vivo expression of said polypeptide.
Claims13
(canceled)
(canceled)
A pharmaceutical composition for cancer treatment of mammalian and/or other vertebrate comprising:
- a pharmaceutically acceptable carrier;
- and
- one or more polypeptides comprising one or more sequences having 70% or greater similarity to SEQ ID No:
- 6, or one or more sequences having 70% identity or greater with SEQ ID No:
- 6;
- or
- one or more gene constructs useful for the expression in mammals and/or other vertebrates of one or more polypeptides as defined above.
(canceled)
A method for the cancer treatment of mammals and/or other vertebrates comprising the use of a pharmaceutical composition comprising:
- one or more polypeptides comprising one or more sequences having equal or greater than 70% of similarity to SEQ ID No:
- 6, or one or more sequences having an equal or greater than 70% of identity with SEQ ID No:
- 6;
- or
- one or more gene constructs useful for the expression of one or more of said polypeptides,
- wherein the mammals and/or other vertebrates are treated with a pharmaceutically effective amount of the pharmaceutical composition.
A process for the preparation of a pharmaceutical composition for cancer treatment of mammalian and/or other vertebrate cancer comprising a mixing step for mixing:
- one or more polypeptides comprising one or more sequences having equal or greater than 70% similarity to SEQ ID No:
- 6, or one or more sequences having an identity equal or greater than 70% identity with SEQ ID No:
- 6;
- or
- one or more gene constructs useful for the expression in mammals and/or other vertebrates of one or more of said polypeptides;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.