Implantable medical devices for optogenetics
AssigneesThe Board of Trustees of the University of Illinois, Washington University in St. Louis
InventorsJohn A. ROGERS, Gunchul SHIN, Anthony R. BANKS, Michael BRUCHAS, Robert GEREAU
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Abstract
Provided are implantable biomedical devices and related methods for interfacing with a target tissue. The devices comprise a substrate, an electronic device supported by the substrate and a freely positionable injectable needle electronically connected to the electronic device by a deformable interconnect, where the injectable needle has one or more optical sources provided on a distal tip end. The injectable needle may further comprise a photodetector.
Claims92
An implantable biomedical device for interfacing with a target tissue, said device comprising:
- a substrate;
- an electronic device supported by said substrate;
- and
- a freely positionable injectable needle electronically connected to said electronic device by a deformable interconnect;
- an optical source connected to said injectable needle;
- wherein said optical source has an emitting area less than or equal to 1×106 μm2.
A system comprising:
- a plurality of implantable biomedical devices for interfacing with a target tissue, each of said implantable biomedical devices comprising:
- a substrate;
- an electronic device supported by said substrate;
- a freely positionable injectable needle electronically connected to said electronic device by a deformable interconnect;
- an optical source connected to said injectable needle;
- wherein said optical source has an emitting area less than or equal to 1×106 μm2;
- an antenna inductively coupled to a coil of each electronic device;
- and
- a photodiode for measuring light emitted or scattered from said target tissue.
An implantable optical system for optically interfacing with a target tissue, said device comprising:
- a substrate;
- an electronic device supported by said substrate;
- said electronic device comprising a wireless system providing for wireless power and data communication;
- and
- an injectable optical probe electronically connected to the electronic device;
- wherein the optical probe comprises one or more optical sources and one or more optical detectors optically collocated along a length and/or near a distal end;
- wherein each optical source is individually characterized by lateral dimensions equal to or less than 1000 μm and wherein each optical detector is individually characterized by lateral dimensions equal to or less than 1000 μm;
- wherein said wireless system at least partially powers said one or more optical sources and one or more optical detectors.
A method of using an implantable optical system for optically interfacing with a target tissue, said method comprising:
- providing an implantable optical system comprising:
- a substrate;
- an electronic device supported by said substrate;
- said electronic device comprising a wireless system providing for wireless power and data communication;
- and an injectable optical probe electronically connected to the electronic device via a deformable interconnect;
- wherein the injectable optical probe comprises one or more optical sources and one or more optical detectors optically collocated along a length and/or near a distal end;
- wherein each optical source is individually characterized by lateral dimensions equal to or less than 1000 μm and wherein each optical detector is individually characterized by lateral dimensions equal to or less than 1000 μm;
- wherein said wireless system at least partially powers said one or more optical sources and one or more optical detectors;
- inserting said injectable optical probe into said target tissue;
- and
- sensing and/or actuating said target tissue with said one or more optical sources and/or said one or more optical detectors.
A method of using an implantable biomedical device for interfacing with a target tissue, the method comprising:
- providing said implantable biomedical device comprising;
- a substrate;
- an electronic device supported by said substrate;
- and
- a freely positionable injectable needle electronically connected to the electronic device by a deformable interconnect;
- said injectable needle having one or more optical sources provided along a length of said injectable needle and/or near a distal tip end of said injectable needle;
- wherein each optical source is individually characterized by an emitting area less than or equal to 1×106 μm2;
- inserting said freely positionable injectable needle into said target tissue;
- and
- actuating said target tissue with said one or more optical sources.
An implantable biomedical device for interfacing with a target tissue, said device comprising:
- a substrate;
- an electronic device supported by said substrate;
- and
- a freely positionable probe electronically connected to the electronic device by a deformable interconnect;
- said probe having one or more optical sources provided along a length of said probe and/or near a distal tip end of said probe;
- wherein each optical source is individually characterized by an emitting area less than or equal to 1×106 μm2.
Dependencies are inferred from the claim text.