System and method for processing genotype information relating to nsaid risk

An apparatus comprising:

• at least one processor;
• and
• at least one memory including computer program code for one or more programs,
• the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to perform at least the following,
• determine patient information, including DNA information, associated with a human subject;
• determine from the DNA information whether a subject genotype of the human subject includes one or more SNP diploid polymorphisms by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more SNP diploid polymorphisms in the subject genotype,
• wherein each SNP diploid polymorphism of the one or more SNP diploid polymorphisms includes a combination of two SNP alleles associated with one SNP location,
• wherein the one or more SNP diploid polymorphisms are selected from the SNP diploid group:
• ABCB1-ANC, ABCB1-HET, and ABCB1-NONA in the ABCB1 gene, COX1-ANC, COX1-HET, and COX1-NONA in the COX1 gene, PTPN11-ANC, PTPN11-HET, and PTPN11-NONA in the PTPN11 gene, NOD1-ANC, NOD1-HET, and NOD1-NONA in the NOD1 gene, TLR4-ANC, TLR4-HET, and TLR4-NONA in the TLR4 gene, CRP-ANC, CRP-HET, and CRP-NONA in the CRP gene, and COMT-ANC, COMT-HET, and COMT-NONA in the COMT gene;
• and
• determine a nonsteroidal anti-inflammatory drug (NSAID) mediated side effect risk associated with the human subject based, at least in part, on the presence or absence of the one or more SNP diploid polymorphisms in the subject genotype.

A non-transitory computer readable medium storing computer readable instructions that when executed by at least one processor perform a method, the method comprising facilitating a processing of and/or processing (1) data and/or (2) information and/or (3) at least one signal, the (1) data and/or (2) information and/or (3) at least one signal based, at least in part, on the following:

• determining patient information, including DNA information, associated with a human subject;
• determining from the DNA information whether a subject genotype of the human subject includes one or more SNP diploid polymorphisms by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more SNP diploid polymorphisms in the subject genotype,
• wherein each SNP diploid polymorphism of the one or more SNP diploid polymorphisms includes a combination of two SNP alleles associated with one SNP location,
• wherein the one or more SNP diploid polymorphisms are selected from the SNP diploid group:
• ABCB1-ANC, ABCB1-HET, and ABCB1-NONA in the ABCB1 gene, COX1-ANC, COX1-HET, and COX1-NONA in the COX1 gene, PTPN11-ANC, PTPN11-HET, and PTPN11-NONA in the PTPN11 gene, NOD1-ANC, NOD1-HET, and NOD1-NONA in the NOD1 gene, TLR4-ANC, TLR4-HET, and TLR4-NONA in the TLR4 gene, CRP-ANC, CRP-HET, and CRP-NONA in the CRP gene, and COMT-ANC, COMT-HET, and COMT-NONA in the COMT gene;
• and
• determining a nonsteroidal anti-inflammatory drug (NSAID) mediated side effect risk associated with the human subject based, at least in part, on the presence or absence of the one or more SNP diploid polymorphisms in the subject genotype.