Time Window-Based Platform for the Rapid Stratification of Blunt Trauma Patients into Distinct Outcome Cohorts

A method of managing a trauma injury patient or a method of determining risk of multiple organ dysfunction in a patient, comprising:

• obtaining within a window of time after injury a patient's values for members of a panel of biomarkers, clinical variables, and/or genetic polymorphisms that are, as a group, able to segregate, using one or more statistical and/or mathematical methods on a data set of a statistically-significant size, patients at least into group of patients that experience high risk, and patients that experience low risk, of multiple organ dysfunction with clinically-acceptable specificity and selectivity;
• determining, using a computer-implemented method, a value for the obtained patient's values for each member of the panel of biomarkers, clinical variables, and/or genetic polymorphisms against a set of stored values for a statistically-significant number of patients, and calculating a representation of those values to produce a panel value;
• determining, using a computer-implemented method, if the panel value for the patient is within a range of panel values for the set of stored values within which patients experience a clinically-relevant risk of multiple organ dysfunction or nosocomial infection;
• and
• producing, using a computer-implemented method, an output indicating whether the patient is expected to experience a risk of multiple organ dysfunction or nosocomial infection.