Scanned line angular projection microscopy

A microscope for imaging a sample, the microscope comprising:

• a first light source configured for generating first excitation light;
• raster scanning optical elements configured for raster scanning the first excitation light through the sample;
• a first detector configured for detecting light emitted from the sample in response to the raster scanned first excitation light;
• a second light source configured for generating second excitation light;
• beam handling optics configured for:
• directing the second excitation light into a plurality of different light beam paths at different times,
• providing the light in each of the plurality of light beam paths through an objective lens to the sample, and
• providing light in each of the plurality of beams to different locations within the sample;
• a second detector configured for detecting fluorescence emission light from the sample in response to excitation by the second excitation light in each of the plurality of light beam paths, wherein the fluorescence emission light detected in response to the second excitation light in different ones of the plurality of light beam paths corresponds to fluorescence intensity projections of the sample with low mutual coherence;
• and
• a processor configured for generating an image of the sample based on the detected light emitted from the sample in response to the raster scanned first excitation light and based on the detected fluorescence emission light emitted from the sample in response to excitation by the second excitation light in each of the plurality of light beam paths.