Back to results
US 2018/0298411 A1Published application
Method of Producing Heparan Sulfate Having Anticoagulant Activity
AssigneeAjinomoto Co., Inc.
InventorYuriko Tokura
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of producing a heparan sulfate having an anticoagulant activity. Specifically, the present invention provides the method of producing a heparan sulfate having a desired molecular weight, by partially N-deacetylating a heparosan followed by depolymerizing the heparosan by heparinase III, and converting the produced low molecular weight product into heparan sulfate having an anticoagulant activity.
Claims12
A method of producing a heparan sulfate having anticoagulant activity, comprising the following steps:
- (A) partially N-deacetylating a heparosan to produce an N-deacetylated heparosan,
- (B) treating the N-deacetylated heparosan with heparinase III to produce a depolymerized N-deacetylated heparosan, and
- (C) sulfating the depolymerized N-deacetylated heparosan to produce the heparan sulfate having anticoagulant activity.
Dependencies are inferred from the claim text.