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AssigneesThe United States of America, as represented by the Secretary, Department of Health and, Human Services
InventorsXiaoyuan Chen, Jibin Song
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Disclosed is a method of producing a vesicle containing a metallic nanoparticle that is covalently bound to at least one hydrophilic polymer and at least one hydrophobic polymer, wherein the method involves dispersing the polymer-bound metallic nanoparticle in an organic solvent, adding an aqueous solution containing a dispersing aid to form a mixed solution, sonicating the mixed solution to form an emulsion; and removing the organic solvent from the emulsion until the vesicle forms. Using this method, the formed vesicle has a diameter of 20-150 nm, which is useful for a method of conducting photothermal therapy (PTT) for killing cells, such as cancer cells.
A method of producing a vesicle comprising a polymer-bound metallic nanoparticle, wherein the method comprises
A vesicle comprising a polymer-bound metallic nanoparticle comprising a metallic nanoparticle that is covalently bound to at least one hydrophilic polymer and at least one hydrophobic polymer, wherein the vesicle has a diameter of 20-150 nm.
Dependencies are inferred from the claim text.