P0 gene silencing constructs and use
AssigneeSESVanderHave NV
InventorsElodie KLEIN, Véronique GRAFF, David GILMER, Véronique BRAULT, Guy WEYENS, Marc LEFEBVRE
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Abstract
A recombinant BMYV P0 viral nucleotide sequence when transcribed in a cell is capable of forming a double stranded self-complementary RNA sequence.
Claims17
A RNA construct comprising a sense segment sequence and an antisense segment sequence having sequences deduced from P0 gene of BMYV genome or from an ortholog gene, wherein said sense segment and said antisense segment sequences both comprise a nucleotide fragment having sequence sharing at least 85% of sequence identity with the P0 gene (SEQ.ID.NO:17) from BMYV genome or from an ortholog gene.
A method for inducing tolerance to at least the BMYV virus comprising the step of preparing a nucleic acid construct comprising a sense and an antisense segments deduced from a BNYVV nucleotide sequence deduced from the gene encoding the P15 protein of the said BNYVV.
Dependencies are inferred from the claim text.