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AssigneeProtein Potential, LLC
InventorsYUN WU, Dennis J. KOPECKO, B. Kim Lee SIM, Stephen L. HOFFMAN
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Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
A transgenic Salmonella typhi Ty21a comprising a heterologous Shigella sonnei O-antigen biosynthetic gene region and a heterologous acid resistance biosynthetic gene system, said O-antigen biosynthetic gene region and said acid resistance biosynthetic gene system both being integrated into the Salmonella typhi Ty21a chromosome, wherein:
(canceled)
A transgenic Salmonella typhi Ty21a comprising a heterologous enterotoxogenic E. coli (ETEC) antigen biosynthetic gene region and a heterologous acid resistance biosynthetic gene system, wherein said ETEC antigen biosynthetic gene region and said acid resistance biosynthetic gene system are both integrated into the Salmonella typhi Ty21a chromosome, and wherein:
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