Methods and compositions for diagnosing brain injury or neurodegeneration
AssigneeImmunArray USA, Inc.
InventorsRACHEL SOREK, KEREN JAKOBI, DONNA EDMONDS
Life of this patent
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Abstract
Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject.
Claims28
A method for detecting brain injury in a subject, the method comprising the steps of:
- (i) obtaining a sample from a subject;
- (ii) contacting the sample with at least one antigen having an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1-115, isoforms thereof, post-translationally modified forms thereof, fragments thereof, or any combinations thereof to determine the reactivity of said at least one antigen with antibodies in the subject's sample;
- (iii) measuring the reactivity of antibodies in the sample relative to the reactivity of antibodies in a healthy control;
- and
- (iv) detecting brain injury in the subject by measuring a difference in the reactivity of the antibodies in the sample compared to the reactivity of the antibodies in the healthy control.
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An article of manufacture comprising an antigen probe set comprising a plurality of antigen probes selected from the group consisting of SEQ ID NOs:
- 1-115, isoforms thereof, post-translationally modified forms thereof, fragments thereof, or any combinations thereof.
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A method for qualifying brain injury status in a subject in need thereof, the method comprising the steps of:
- (i) obtaining a sample from a subject;
- (ii) determining the reactivity of antibodies in the sample to at least one antigen having an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1-115, isoforms thereof, post-translationally modified forms thereof, fragments thereof, or any combinations thereof by contacting the sample with the at least one antigen;
- (iii) measuring the reactivity of antibodies in the sample to a predefined reactivity that identifies one or more brain injury statuses selected from the group consisting of having brain injury, not having brain injury, predisposition to brain injury, sub-acute brain injury, acute brain injury, post-acute brain injury, progressing brain injury, regressing brain injury, subclinical brain injury, mild brain injury, moderate brain injury, severe brain injury and chronic brain injury;
- and
- (iv) qualifying brain injury status in the subject as indicated by the measured reactivity in the subject's sample correlating to one of the predefined reactivities.
A method of detecting recovery from brain injury in a subject, the method comprising the steps of:
- (i) obtaining a sample from the subject;
- (ii) determining the reactivity of antibodies in the sample to at least one antigen having an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 10, 61, 104, isoforms thereof, post-translationally modified forms thereof, fragments thereof, or any combinations thereof by contacting the sample with the at least one antigen;
- (iii) assaying the reactivity of antibodies in the sample relative to a predefined reactivity threshold;
- and
- (iv) detecting a difference in the reactivity of the antibodies in the sample compared to the predefined reactivity threshold, thereby indicating recovery from brain injury in said subject.
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Dependencies are inferred from the claim text.