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US 2018/0024138 A1Published application
Frizzled-4 mutation indicator of retinopathy and intrauterine growth restriction
AssigneeRetinal Solutions LLC
InventorsKimberly Drenser, Michael T. Trese, Antonio Capone
Life of this patent
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Abstract
A method for determining the necessity of a pre-term birth treatment is provided based on obtaining a biological sample from a subject. The biological sample is analyzed for the presence of (P33S;P168S) Frizzled4 (Fzd4) gene variation. The subject or a fetus thereof is then treated for a proclivity to pre-term birth. The Fzd4 protein itself can also be analyzed for the (P33S;P168S) Fzd4 mutation.
Claims16
A method for determining the necessity of a pre-term birth treatment comprising:
- obtaining a biological sample from a subject;
- analyzing the biological sample for the presence of (P33S;P168S) Frizzled4 (Fzd4) gene variation;
- and
- treating the subject for pre-term birth complications.
1 more element
A method of pre-term birth treatment comprising:
- contacting a biological sample from a pregnant subject with an antibody directed against a (P33S;P168S) Frizzled4 protein to produce an antibody-protein complex\;
- detecting with Western blot or an ELISA the presence of the antibody-protein complex;
- and
- treating the pregnant subject or a fetus therein to mitigate pre-term birth of the fetus.
1 more element
A method for treating retinopathy of prematurity (ROP) comprising:
- obtaining a biological sample from a subject;
- analyzing the biological sample for the presence of (P33S;P168S) Frizzled4 (Fzd4) gene variation;
- and
- treating the subject for ROP.
1 more element
Dependencies are inferred from the claim text.