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US 2018/0024115 A9Published application
Screening method
AssigneeHoffmann-La Roche Inc.
InventorsMartin Ebeling, Friedrich Metzger, Manaswini Sivaramakrishnan
Life of this patent
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Abstract
The invention discloses a screening method for the identification of new compounds for use in the treatment of cancer.
Claims17
A compound modifying splicing of the FoxM1 gene for use in the prophylaxis or treatment of cancer, wherein the compound induces a transcriptionally inactive FoxM1 variant.
A method of screening for compounds for the prophylaxis or treatment of cancer comprising:
- c) contacting proliferating cells expressing the FoxM1 gene with a test compound,
- d) measuring the FoxM1 variant FoxM1A in the cells of step a), wherein an increased level of the FoxM1A variant compared to a control is indicative for a compound for the prophylaxis or treatment of cancer.
A method of screening for compounds for the prophylaxis or treatment of cancer comprising:
- c) contacting proliferating cells expressing the FoxM1 gene with a test compound,
- d) measuring the FoxM1 variant FoxM1B and/or variant FoxM1C in the cells of step a), wherein a decreased level of the variant FoxM1B and/or variant FoxM1C compared to a control is indicative for a compound for the prophylaxis or treatment of cancer.
The invention as described herein before.
Dependencies are inferred from the claim text.