Tissue Culture Tray and System for the In Vitro Testing and Characterization of Magnetically-Induced Rotation and Translational Motion of Magnetic Particles

A tissue culture plate or tray for magnetically induced rotational and translational movement of magnetic particles, the tissue culture plate or tray comprising:

• a plate base having an upper surface and a plurality of sides, the plate base having a form factor of a truncated cuboid, wherein the plate base is comprised of a material compatible with an imaging technique selected from the group consisting of magnetic resonance imaging, x-ray imaging, computed tomography (CT) imaging, ultrasound imaging, light microscopy, fluorescence microscopy, and combinations thereof;
• and
• a plurality of channels arranged in the plate base, each channel of the plurality of channels spaced apart from one or more sides of the plurality of sides, each channel of the plurality of channels having a predetermined depth from the upper surface of the plate base, and each channel of the plurality of channels further having a length and a width, wherein the length is greater than the width;
• wherein the plurality of channels are arranged as a plurality of straight or curved branches of a central channel of the plurality of channels, the central channel having a first width or diameter and the plurality of branching channels having widths or diameters which are successively or incrementally smaller than the first width or diameter.

A system for magnetically induced rotary translational movement of magnetic particles in a tissue culture plate or tray, the system comprising:

• a magnetic device to generate a rotating magnetic field having a time-varying amplitude and polarity;
• and
• a tissue culture plate or tray spaced-apart from the magnetic device a predetermined lateral distance and elevation, the tissue culture plate or tray comprising:
• a plate base having an upper surface and a plurality of sides, the plate base having a form factor of a truncated cuboid;
• a plurality of channels arranged in the plate base, each channel of the plurality of channels spaced apart from one or more sides of the plurality of sides, each channel of the plurality of channels having a predetermined depth from the upper surface of the plate base, each channel of the plurality of channels further having a length and a width, wherein the length is greater than the width.