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US 2018/0024048 A1Published application
Optical technique for coating characterization
AssigneeCook Medical Technologies LLC
InventorsJohn Neilan, Syed A.M. Tofail, Rabah Mouras, Christophe Silien, Aladin Mani, David Murray
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Abstract
The present invention generally relates to methods for determining the presence and distribution of a polarization active material present in a coating. In one embodiment, the coating is present on an implantable device, for example an implantable stent.
Claims18
A method for determining a distribution of a first polarization active compound in a coating, comprising:
- utilizing optical microscopy to obtain images at a plurality of planes at differing axial positions between an upper and a lower boundary of the coating;
- measuring a distribution of polarization activity within each of the images, wherein the distribution is based on a distribution in polarization of light within the plurality of images;
- constructing a three dimensional distribution based on the distribution of polarization active material within each of the plurality of images;
- and
- determining the distribution of the first polarization active compound in the coating based on the three dimensional polarization activity distribution.
2 more elements
A method for determining a distribution of a crystalline paclitaxel polymorph in a coating, comprising:
- utilizing optical microscopy to obtain images at a plurality of focal planes at differing axial positions between an upper and a lower boundary of the coating;
- measuring a polarization activity distribution within each of the plurality of images, wherein the polarization activity distribution is based on a distribution in polarization of light within the plurality of images;
- constructing a three dimensional birefringence distribution based on the polarization activity distribution within each of the plurality of images;
- and
- determining the distribution of the crystalline paclitaxel polymorph in the coating based on the three dimensional polarization activity distribution,
- wherein the coating is a coating on an on an implantable vascular stent.
3 more elements
Dependencies are inferred from the claim text.