3.beta-hydroxysteroid dehydrogenase in steroid dependent disease
AssigneeThe Cleveland Clinic Foundation
InventorsNima Sharifi, Kai-Hsiung Chang
Life of this patent
Estimating the term…
Abstract
Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a biological sample from the subject, determining if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed is also described.
Claims19
A method of treating a steroid-dependent disease in a subject in need thereof, comprising:
- determining that a cytosine nucleotide is present at position 1245 of the HSD3B1 gene or a threonine is present at position 367 of the 3bHSD1 protein by assaying a biological sample from the subject, and
- administering treatment to the subject selected from the group consisting of salvage cryotherapy, radiation therapy, radical prostatectomy, proton therapy, and high intensity focused ultrasound, or continuing steroid ablation together with administration of an androgen receptor antagonist, administration of an androgen synthesis inhibitor, or administration of a 3βHSD1 inhibitor to the subject.
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A kit for guiding treatment of steroid-dependent disease in a subject comprising:
- one or more primers or probes capable of detecting 3βHSD1 (367T) or HSD3B1(1245C), and a package for holding the primers or probes.
Dependencies are inferred from the claim text.