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AssigneePurac Biochem B.V.
InventorsNick Johannes Petrus Wierckx, Tom Daniel Elink Schuurman, Sipko Maarten Kuijper, Harald Johan Ruijssenaars
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The present invention relates to the field of biotransformation of furanic compounds. More particular the present invention relates to novel genetically modified cells with improved characteristics for biocatalytic transformation of furanic compounds and a vector suitable for the genetic modification of a host cell. Further aspects of the invention are aimed at processes for biotransformation of 5-(hydroxymethyl)furan-2-carboxylic acid (HMF-acid) and its precursors with the use of the cell according to the invention.
1-24. (canceled)
A process for producing 2,5-furandicarboxylic acid (FDCA), the process comprising the step of incubating a cell in the presence of one or more furanic precursors of HMF-acid under conditions suitable for the oxidation by said cell of the one or more furanic precursors to FDCA, wherein said conditions include that the cell is incubated at a pH from pH 1 to 6, and wherein the cell is genetically modified to express a polynucleotide sequence coding for a polypeptide having HMF-acid oxidoreductase activity.
Dependencies are inferred from the claim text.