Compositions and Methods for Inhibiting Gene Expression of Factor XII

A composition comprising:

• RNA interference (RNAi) trigger molecule capable of inhibiting the expression of an Factor XII gene, wherein said RNAi trigger molecule comprises a sense strand and an antisense strand, wherein said antisense strand comprises any of the antisense sequences in Table 1 and Table 2, and at least one pharmaceutically acceptable excipient.

A method for inhibiting Factor XII expression in a subject comprising:

• administering to said subject a therapeutically effective amount of an RNA interference (RNAi) trigger capable of inhibiting the expression of an F12 gene wherein said RNAi trigger comprises a sense strand and an antisense strand, wherein said antisense strand comprises any of the antisense sequences in Table 1 and Table 2.