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AssigneeJohann Wolfgang Goethe-Universität Frankfurt am Main
InventorsStefanie DIMMELER, Nicolas JAÉ, Niels BOECKEL, Andreas M. ZEIHER
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The present invention associates multiple circular (circRNA) with key functions of endothelial cells. The present invention provides circRNA transcripts that are correlated with cardiovascular diseases, in particular acute myocardial infarction. The circRNA of the invention therefore serve as biomarkers in the diagnosis of cardiovascular disorders. The invention provides the new nucleic acid molecules as well as diagnostic kits and compositions comprising the nucleic acids. Modulation of the expression of the circRNA of the invention further leads to endothelial cell sprouting, and therefore is applied as a treatment for cardiovascular diseases or pathological angiogenesis. The invention provides therapeutic agents modulating circRNA expression or function. Further aspects of the invention provide novel circRNA for the treatment of inflammatory diseases.
A nucleic acid, comprising
An in-vitro or ex-vivo method of predicting, monitoring and/or diagnosing a cardiovascular disease in a subject, comprising the steps of:
(canceled)
A compound for use in the treatment of a proliferative disease or a disease associated with endothelial cell dysfunction, wherein the compound is an agonist of or is an antagonist of, a non-coding circular RNA (circRNA) comprising a sequence shown in any of SEQ ID NO:
A compound for use in the treatment of a disease associated with inflammation, wherein the compound is an agonist of or is an antagonist of, a non-coding circular RNA (circRNA) comprising a sequence shown in [SEQ ID NO:
An in-vitro or ex-vivo method for modulating endothelial cell function comprising contacting an endothelial cell with an agonist or antagonist of a circRNA, wherein the circRNA comprises a sequence shown in any of SEQ ID NO:
An in-vitro or ex-vivo method for the generation of vascular tissue material, the method comprising the steps of contacting an endothelial cell with an antagonist of a circRNA comprising a sequence shown in SEQ ID NO:
A method of in-vitro or ex-vivo modulation of endothelial cell function, comprising the step of contacting an endothelial cell with an agonist or antagonist of a circRNA comprising a sequence shown in any of SEQ ID NO:
Dependencies are inferred from the claim text.