Loading patent…
AssigneeBiocant-AssociaçãO De TransferêNcia De Tecnologia
InventorsHelena Sofia ESMERALDO DE CAMPOS VAZÃO, Lino DA SILVA FERREIRA, Hugo Agostinho MACHADO FERNANDES
Estimating the term…
The present disclosure relates to a differentiated cell population of endothelial cells derived from human pluripotent stem cells. The present invention also relates to a composition, a system and a kit comprising those cells and uses thereof. The present disclosure also described the combination of arterial ECs derived from human pluripotent stem cells with a microfluidic system to create a vascular kit for high-throughput drug screening and/or toxicology analysis. This technology may find particular use for the identification of drugs that may have a fetal cytotoxic effect.
1-41. (canceled)
A method for screening compounds that interfere with embryonic vascular development or has fetal cytotoxic effect, said method comprises providing a system comprising a channel with millimeter or micrometer dimension and a population of differentiated endothelial cells derived from human pluripotent stem cells wherein a portion of the endothelial cells express ephrin B2, and wherein the endothelial cells are cultured under physiologic shear stress.
Dependencies are inferred from the claim text.