Oxidized dextran
AssigneeE. I. Du Pont de Nemours and Company
InventorsJayme L. Paullin, Rakesh Nambiar
Life of this patent
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Abstract
Compositions comprising oxidized dextran compounds are disclosed herein. Oxidized dextran compounds are produced by contacting dextran under aqueous conditions with at least one N-oxoammonium salt, at least one periodate compound, and/or at least one peroxide compound.
Claims15
A composition comprising an oxidized dextran compound, wherein the oxidized dextran compound is produced by contacting dextran under aqueous conditions with at least one N-oxoammonium salt, at least one periodate compound, and/or at least one peroxide compound,
- wherein the dextran comprises:
- (i) about 87-93 wt % glucose linked at positions 1 and 6;
- (ii) about 0.1-1.2 wt % glucose linked at positions 1 and 3;
- (iii) about 0.1-0.7 wt % glucose linked at positions 1 and 4;
- (iv) about 7.7-8.6 wt % glucose linked at positions 1, 3 and 6;
- and
- (v) about 0.4-1.7 wt % glucose linked at:
- (a) positions 1, 2 and 6, or
- (b) positions 1, 4 and 6;
- and wherein the weight-average molecular weight (Mw) of the dextran is about 50-200 million Daltons and the z-average radius of gyration of the dextran is about 200-280 nm.
A method of producing an oxidized dextran compound, the method comprising:
- (a) contacting dextran under aqueous conditions with at least one N-oxoammonium salt, at least one periodate compound, and/or at least one peroxide compound,
- wherein the dextran comprises:
- (i) about 87-93 wt % glucose linked at positions 1 and 6;
- (ii) about 0.1-1.2 wt % glucose linked at positions 1 and 3;
- (iii) about 0.1-0.7 wt % glucose linked at positions 1 and 4;
- (iv) about 7.7-8.6 wt % glucose linked at positions 1, 3 and 6;
- and
- (v) about 0.4-1.7 wt % glucose linked at:
- (a) positions 1, 2 and 6, or
- (b) positions 1, 4 and 6;
- wherein the weight-average molecular weight (Mw) of the dextran is about 50-200 million Daltons and the z-average radius of gyration of the dextran is about 200-280 nm;
- wherein the dextran is oxidized by the N-oxoammonium salt, periodate compound, and/or peroxide compound thereby producing an oxidized dextran compound, and
- (b) optionally, isolating the oxidized dextran compound.
Dependencies are inferred from the claim text.