Method for the treatment of multiple myeloma or non-hodgkins lymphoma with anti-cd38 antibody and bortezomib or carfilzomib

A method for treating multiple myeloma or non-hodgkins lymphoma in a subject in need thereof, wherein said method comprises administering to the subject a therapeutically effective amount of a combination of:

• (i) thalidomide, lenalidomide or pomalidomide, (ii) an antibody specific for CD38, comprising an HCDR1 region of sequence SYYMN (SEQ ID NO:
• 14) or GFTFSSYYMN (SEQ ID NO:
• 1), an HCDR2 region of sequence GISGDPSNTYYADSVKG (SEQ ID NO:
• 2), an HCDR3 region of sequence DLPLVYTGFAY (SEQ ID NO:
• 3), an LCDR1 region of sequence SGDNLRHYYVY (SEQ ID NO:
• 4), an LCDR2 region of sequence GDSKRPS (SEQ ID NO:
• 5), and an LCDR3 region of sequence QTYTGGASL (SEQ ID NO:
• 6).

A method for treating multiple myeloma or non-hodgkins lymphoma in a subject in need thereof, wherein said method comprises administering to the subject a therapeutically effective amount of a combination of:

• thalidomide and an antibody specific for CD38, comprising an HCDR1 region of sequence SYYMN (SEQ ID NO:
• 14) or GFTFSSYYMN (SEQ ID NO:
• 1), an HCDR2 region of sequence GISGDPSNTYYADSVKG (SEQ ID NO:
• 2), an HCDR3 region of sequence DLPLVYTGFAY (SEQ ID NO:
• 3), an LCDR1 region of sequence SGDNLRHYYVY (SEQ ID NO:
• 4), an LCDR2 region of sequence GDSKRPS (SEQ ID NO:
• 5), and an LCDR3 region of sequence QTYTGGASL (SEQ ID NO:
• 6).

A method for treating multiple myeloma or non-hodgkins lymphoma in a subject in need thereof, wherein said method comprises administering to the subject a therapeutically effective amount of a combination of:

• lenalidomide and an antibody specific for CD38, comprising an HCDR1 region of sequence SYYMN (SEQ ID NO:
• 14) or GFTFSSYYMN (SEQ ID NO:
• 1), an HCDR2 region of sequence GISGDPSNTYYADSVKG (SEQ ID NO:
• 2), an HCDR3 region of sequence DLPLVYTGFAY (SEQ ID NO:
• 3), an LCDR1 region of sequence SGDNLRHYYVY (SEQ ID NO:
• 4), an LCDR2 region of sequence GDSKRPS (SEQ ID NO:
• 5), and an LCDR3 region of sequence QTYTGGASL (SEQ ID NO:
• 6).

A method for treating multiple myeloma or non-hodgkins lymphoma in a subject in need thereof, wherein said method comprises administering to the subject a therapeutically effective amount of a combination of:

• pomalidomide and an antibody specific for CD38, comprising an HCDR1 region of sequence SYYMN (SEQ ID NO:
• 14) or GFTFSSYYMN (SEQ ID NO:
• 1), an HCDR2 region of sequence GISGDPSNTYYADSVKG (SEQ ID NO:
• 2), an HCDR3 region of sequence DLPLVYTGFAY (SEQ ID NO:
• 3), an LCDR1 region of sequence SGDNLRHYYVY (SEQ ID NO:
• 4), an LCDR2 region of sequence GDSKRPS (SEQ ID NO:
• 5), and an LCDR3 region of sequence QTYTGGASL (SEQ ID NO:
• 6).