Treatment of autoimmune disorders with cd154 antibodies

A method of treating an autoimmune, inflammatory, neurodegenerative or neuromuscular disorder in a mammalian subject comprising:

• a) administering an initial loading dose of about 20-60 mg/kg of antibody or antibody fragment binding specifically to CD154 to a subject in need of such treatment;
• and
• b) about 2 weeks after the initial loading dose administering a further dose or doses of about half of the initial loading dose with a frequency of about once every other week of antibody or antibody fragment binding specifically to CD154 to the subject in need of such treatment.