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US 2018/0022809 A1Published application
Anti-pd-l1 antibodies and diagnostic uses thereof
AssigneesGenentech, Inc., Spring BioScience Corporation, Ventana Medical Systems, Inc.
InventorsMarcin KOWANETZ, Hartmut KOEPPEN, Zachary BOYD, Zhiming LIAO, Yifei ZHU, Bharathi VENNAPUSA, Patrick C. ROCHE
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Abstract
The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.
Claims78
An isolated antibody that specifically binds to PD-L1, wherein the antibody binds to an epitope comprising amino acid residues 279-290 of human PD-L1 polypeptide (SEQ ID NO:
- 1).
The antibody of claim 11, wherein the antibody comprises the following hypervariable regions (HVRs):
- (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO:
- 2);
- (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO:
- 3);
- and
- (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO:
- 4).
4 more elements
An isolated antibody that specifically binds PD-L1, wherein the antibody comprises the following HVRs:
- (a) an HVR-H1 comprising the amino acid sequence of SNGLT (SEQ ID NO:
- 2);
- (b) an HVR-H2 comprising the amino acid sequence of TINKDASAYYASWAKG (SEQ ID NO:
- 3);
- (c) an HVR-H3 comprising the amino acid sequence of IAFKTGTSI (SEQ ID NO:
- 4);
- (d) an HVR-L1 comprising the amino acid sequence of QASESVYSNNYLS (SEQ ID NO:
- 9);
- (e) an HVR-L2 comprising the amino acid sequence of LASTLAS (SEQ ID NO:
- 10);
- and
- (f) an HVR-L3 comprising the amino acid sequence of IGGKSSSTDGNA (SEQ ID NO:
- 11).
10 more elements
Dependencies are inferred from the claim text.