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AssigneeMedImmune, LLC
InventorsSrinath KASTURIRANGAN, CHANGSHOU GAO, GODFREY RAINEY, MICHELLE MORROW, CLAIRE LOUISE DOBSON, STACEY DRABIC, DARREN SCHOFIELD, GIANLUCA CARLESSO, KRISTEN POLLIZZI, YARIV MAZOR, MICHAEL OBERST, SCOTT A. HAMMOND, BRIAN LOBO, PRAKASH MANIKWAR, JONATHAN SEAMAN
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The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.
A protein, comprising:
A bispecific binding protein that binds to PD-1 and CTLA-4 comprising a first peptide comprising the amino acid sequence of SEQ ID NO:1, and a second peptide the amino acid sequence of SEQ ID NO:2.
A bispecific binding protein that binds to PD-1 and CTLA-4 comprising a first peptide comprising the amino acid sequence of SEQ ID NO:3, and a second peptide comprising the amino acid sequence of SEQ ID NO:4.
A bispecific binding protein that binds to PD-1 and CTLA-4 comprising, a first peptide comprising the amino acid sequence of SEQ ID NO:5, and a second peptide comprising the amino acid sequence of SEQ ID NO:6.
A bispecific binding protein that binds to PD-1 and CTLA-4 comprising a first heavy chain comprising the amino acid sequence of SEQ ID NO:
A bispecific binding protein that binds to PD-L1 and CTLA-4 comprising a first peptide comprising the amino acid sequence of SEQ ID NO:14 and a second peptide comprising the amino acid sequence of SEQ ID NO:15.
A bispecific binding protein that binds to PD-L1 and CTLA-4 comprising a first peptide comprising the amino acid sequence of SEQ ID NO:16, and a second peptide comprising the amino acid sequence of SEQ ID NO:17.
A bispecific binding protein that binds to PD-L1 and CTLA-4 comprising a first peptide comprising the amino acid sequence of SEQ ID NO:18, and a second peptide comprising the amino acid sequence of SEQ ID NO:19.
43-51. (canceled)
Dependencies are inferred from the claim text.