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US 2018/0022797 A1Published application
Transthyretin antibodies and uses thereof
AssigneeMisfolding Diagnostics, Inc.
InventorsXin JIANG, Jeffery W. KELLY, Justin CHAPMAN
Life of this patent
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Abstract
The present invention provides compositions comprising anti-transthyretin antibodies. The compositions are particularly useful for diagnosis, prognosis and/or treatment of amyloid diseases or symptoms thereof.
Claims19
A method of administering an anti-aggregate agent to a subject in need thereof, comprising:
- a) administering said anti-aggregate agent to said subject at multiple time points;
- b) measuring a level of non-native TTR in said subject upon at least a first and second time point of said administration;
- c) adjusting dosage of said anti-aggregate agent and/or selecting a different anti-aggregate agent for administration based on said detected level of non-native TTR.
A method of assessing the efficacy of an anti-aggregate therapy applied to a subject, comprising:
- measuring a change in the level of non-native TTR in said subject during said therapy, wherein said measuring is performed using an antibody that exhibits selective binding to non-native TTR under physiologically relevant conditions as compared to tetrameric TTR for said antibody binding, and wherein a decrease in the level of non-native TTR during said therapy indicates that said therapy is efficacious.
Dependencies are inferred from the claim text.