Biological Materials and Uses Thereof
AssigneeImperial Innovations Limited
InventorsKim Suzanne Midwood, Brian Maurice John Foxwell
Life of this patent
Estimating the term…
Abstract
There is provided agents for modulation of a chronic inflammatory response wherein the agent modulates the biological activity of tenascin-C. There is also provided methods of identifying agents modulating tenascin-C and chronic inflammation. There are also provided uses of such agents.
Claims34
1-91. (canceled)
An agent for modulation of a chronic inflammatory response, wherein the agent modulates the biological activity of tenascin-C by altering the transcription, translation and/or binding properties of tenascin-C.
An agent for modulation of a chronic inflammatory response comprising at least one nucleic acid effective to inhibit expression of tenascin-C in a target cell, said nucleic acid hybridizing to a tenascin-C encoding nucleic acid thereby inhibiting expression thereof, said inhibition of tenascin-C expression reducing expression of at least one inflammatory cytokine.
A method of identifying an agent that modulates the activity of tenascin-C activity in a cell comprising:
- (i) incubating at least one cell and tenascin C in the presence and absence of at least one candidate agent;
- (ii) determining whether said candidate agent modulates the effect of tenascin-C on said at least one cell relative to cells as compared to cells incubated in the absence of said agent.
Dependencies are inferred from the claim text.