6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl-substituted imidazopyridazines

A compound of general formula (I):

• in which:
• R1 represents a C2-C6-alkyl- or a C3-C6-cycloalkyl- group which is substituted with a group A, and which is optionally substituted, one, two or three times, independently from each other, with a substituent selected from:
• a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C3-C6-cycloalkyl-, phenyl optionally substituted one or more times, independently from each other, with an R substituent;
• heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent;
• —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OH, or —C(═O)OR′ group;
• in which the group A represents a substituent selected from:
• a —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —N(H)S(═O)R′, —N(R′)S(═O)R″, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, or —OC(═O)N(R′)R″ group,
• or:
• an azetidinyl group, or a 5- to 7-membered nitrogen-containing heterocycloalkyl group,
• in which said 5- to 7-membered nitrogen-containing heterocycloalkyl group one carbon atom is optionally replaced by a further heteroatom-containing group selected from the group consisting of NH, O, S, S(═O) and S(═O)2, and in which said 5- to 7-membered nitrogen-containing heterocycloalkyl group one additional ring atom is optionally replaced by C(═O);
• said azetidinyl group and said 5- to 7-membered nitrogen-containing heterocycloalkyl group being optionally substituted one or two times, independently from each other, with a substituent selected from:
• a halogen atom, a C1-C3-alkyl-, C1-C3-haloalkyl-, or C3-C4-cycloalkyl group;
• R2 represents a substituent selected from:
• a hydrogen atom or a C1-C6-alkyl group;
• R represents a substituent selected from:
• a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C3-C6-cycloalkyl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OH, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, or —S(═O)2N(R′)R″ group;
• R′ and R″ represent, independently from each other, a substituent selected from:
• a C1-C6-alkyl-, C3-C6-cycloalkyl-, C1-C6-haloalkyl-, C1-C6-alkoxy-C2-C6-alkyl-, or C1-C6-haloalkoxy-C2-C6-alkyl- group;
• or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.