Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release
AssigneeRosalind Franklin University of Medicine and Science
InventorsGrace E. Stutzmann, Russell Dahl, Christopher H. Kaiho
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Abstract
Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.
Claims6
1-31. (canceled)
A method for normalizing neuronal calcium dyshomeostasis in a subject in need thereof comprising administering to the subject and effective amount of the compound selected from the group consisting of:
- and a pharmaceutically acceptable salt thereof.
A method for treating a neurological or neurodegenerative disorder in a subject comprising administering to the subject an effective amount of the compound
- and a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.