Negative allosteric modulators of metabotropic glutamate receptor 3

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein
• A is aryl, heteroaryl, heterocycle, or cycloalkyl;
• Z is a bond, O, S, NR2, or CR1gR1h;
• X is —(CR1eR1f)m, O, S, NR2, —C(O)—, —O—C(O)—, —C(O)—O—, —O—C(O)—NR2—, —C(O)—NR2—, —NR2—C(O)—, —NR2—C(O)—O—, —NR2—C(O)—NR2—, —NR2—SO2—, —SO—, or —SO2—;
• R1e, R1f, R1g and R1h are each independently hydrogen, halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, or C1-C3 haloalkoxy;
• m is 1-3;
• R2 is hydrogen, C1-C3 alkyl or C1-C3 haloalkyl;
• R1a, R1b, R1c, and R1d are each independently hydrogen, halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, or C1-C3 haloalkoxy;
• Q is N or CR3a;
• V is N or CR3b;
• W is N or CR3c;
• wherein no more than one of Q, V and W is N;
• R3a, R3b, and Rc are hydrogen, cyano, halogen, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 haloalkyl, or C1-C3 haloalkoxy;
• and
• Y is aryl, heteroaryl, cycloalkyl, or heterocycle;
• wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.