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US 2018/0022708 A1Published application
Processes for preparing ask1 inhibitors
AssigneeGilead Sciences, Inc.
InventorsBrandon Heath Brown, Troy Reynolds
Life of this patent
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Abstract
The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
Claims11
A method for preparing a compound of formula (A):
- or a salt or solvate thereof,
- comprising the steps of:
- (a) carboxylating a compound of formula (E) or a salt thereof:
- under reaction conditions sufficient to form a compound of formula (D) or a hydrate, solvate, or salt thereof:
- (b) chlorinating a compound of formula (D) or a hydrate, solvate or salt thereof under reaction conditions sufficient to form a compound of formula (B) or a salt thereof:
- and
- (c) contacting a compound of formula (B) or a salt thereof with a compound of formula (C) or a salt thereof:
- under reaction conditions sufficient to yield a compound of formula (A).
5 more elements
-152. (canceled)
Dependencies are inferred from the claim text.