Therapeutic compounds and uses thereof

A compound of formula (I):

• or a salt thereof, wherein:
• X is C(═O) or S(O)2;
• R1 is selected from the group consisting of N-linked piperazinyl, N-linked piperidine, and N-linked diazabicyclo[3.2.1]octane, wherein R1 is optionally substituted with one or more groups independently selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, aryl, 3-10 membered heterocycle, and C3-8cycloalkyl, wherein any aryl, 3-10 membered heterocycle, and C3-8cycloalkyl is optionally substituted with one or more groups independently selected from halo, C1-4alkyl, C2-4alkenyl, and C2-4alkynyl, and wherein any C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more groups independently selected from halo, C1-4alkoxy, and C3-8cycloalkyl that is optionally substituted with C1-6alkyl;
• R2 and R3 are each independently selected from H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and C3-8cycloalkyl, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and C3-8cycloalkyl is optionally substituted with one or more groups independently selected from halo and oxo;
• or R2 and R3 taken together with the carbon to which they are attached form a 3-, 4-, 5-, or 6-membered carbocyclic ring that is optionally substituted with one or more groups independently selected from halo, oxo, C1-4alkyl, C2-4alkenyl, and C2-4alkynyl;
• R4 and R5 are each independently selected from H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and C3-8cycloalkyl, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and C3-8cycloalkyl is optionally substituted with one or more groups independently selected from halo and oxo;
• or R4 and R5 taken together with the carbon to which they are attached form a 3-, 4-, 5-, or 6-membered carbocyclic ring that is optionally substituted with one or more groups independently selected from halo, oxo, C1-4alkyl, C2-4alkenyl, and C2-4alkynyl;
• R6 is a 5-10 membered heteroaryl, 5-10 membered heterocycle, or a 6-10 membered aryl, which 5-10 membered heteroaryl, 5-10 membered heterocycle, and 6-10 membered aryl is optionally substituted with one or more groups independently selected from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocycle, heterocycle, aryl, heteroaryl, halo, —NO2, —N(Rb)2, —CN, —C(O)—N(Rb)2, —S(O)—N(Rb)2, —S(O)2—N(Rb)2, —O—Rb, —S—Rb, —O—C(O)—Rb, —C(O)—Rb, —C(O)—ORb, —S(O)—Rb, —S(O)2—Rb, —N(Rb)—C(O)—Rb, —N(Rb)—S(O)—Rb, —N(Rb)—C(O)—N(Rb)2, and —N(Rb)—S(O)2—Rb;
• wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocycle, heterocycle, aryl, and heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halo, —NO2—N(Rb)2, —CN, —C(O)—N(Rb)2, —S(O)—N(Rb)2, —S(O)2—N(Rb)2, —O—Rb, —S—Rb, —O—C(O)—Rb, —C(O)—Rb, —C(O)—ORb, —S(O)—Rb, —S(O)2—Rb, —N(Rb)—C(O)—Rb, —N(Rb)—S(O)—Rb, —N(Rb)—C(O)—N(Rb)2, —N(Rb)—S(O)2—Rb, and C1-6alkyl that is optionally substituted with one or more groups independently selected from halo;
• each Rb is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, aryl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, aryl, and C2-6alkynyl is optionally substituted with one or more groups independently selected from the group consisting of halo, —N(Rc)2, —CN, —C(O)—N(Rc)2, —S(O)—N(Rc)2, —S(O)2—N(Rc)2, —S—Rc, —O—C(O)—Rc, —C(O)—Rc, —C(O)—ORc, —S(O)—Rc, —S(O)2—Rc, —N(Rc)—C(O)—Rc, —N(Rc)—S(O)—Rc, —N(Rc)—C(O)—N(Rc)2, and —N(Rc)—S(O)2—Rc;
• or two Rb are taken together with the nitrogen to which they are attached to form a pyrrolidino, piperidino, or piperazino ring;
• and
• each Rc is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo, amino, hydroxy, and C1-6alkoxy;
• or two Rc are taken together with the nitrogen to which they are attached to form a heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3alkyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo and halo;
• provided that when:
• X is S(O)2;
• R1 is an optionally substituted piperazin-1-yl;
• and
• R2—R5 are each H;
• then R6 is not:
• 2,5-dimethoxyphenyl, 3,4-dimethylphenyl, 4-ethylphenyl, 4-bromophenyl, 2,4-dimethylphenyl, 4-ethoxyphenyl, 4-chloro-2-methoxyphenyl, 4-propylphenyl, 2-(trifluoromethyl)phenyl, 2,4,5-trimethylphenyl, 3-methylphenyl, 2-(methylcarbonylamino)-5-methylphenyl, 4-chlorophenyl, 4-(i sopropyl)phenyl, 3-chloro-4-fluorophenyl, 4-cyclohexylphenyl, 4-(isobutyl)phenyl, 2-methylphenyl, 4-acetylphenyl, 4-(tert-butyl)phenyl, 4-(methylcarbonylamino) phenyl, 2-fluorophenyl, phenyl, 3,5-dimethylphenyl, 4-methylphenyl, 5-fluoro-2-methylphenyl, 4-fluorophenyl, 5,6,7,8-tetrahydronaphthlene-2-yl, 2,4,6-trimethylphenyl, 3-chloro-4-fluorophenyl, 4-(ethoxycarbonylamino)phenyl, 2,5-difluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-methoxyphenyl, 2-methoxy-4-chlorophenyl, or
• and provided that when:
• X is S(O)2;
• R1 is 4-benzylpiperidino;
• and
• R2—R5 are each H;
• then R6 is not 4-methylphenyl
• and provided that when:
• X is C(═O);
• R1 is an optionally substituted piperazin-1-yl;
• and
• R2—R5 are each H;
• then R6 is not:
• 2-methoxyphenyl, 2-methylphenyl, 2-chlorophenyl, 4-ethylphenyl, 3,5-dimethylphenyl, 2,3-dimethoxyphenyl, 4-methylphenyl, 4-ethoxyphenyl, 3,4-dimethylphenyl, 2,3-benzodioxazol-5-yl, 3-chlorophenyl, 3-methylphenyl, 4-methoxyphenyl, 3,5-dimethoxyphenyl, 2-fluorophenyl, 4-fluorophenyl, 3-fluoro-4-methylphenyl, 2,3-dimethoxyphenyl, 4-(tert-butyl)phenyl, 3,4,5-trimethoxyphenyl, 2-bromophenyl, 4-chlorophenyl, 2-trifluoromethylphenyl, phenyl, 4-bromophenyl, 3,4-difluorophenyl, 2,6-difluorophenyl, 2-(dimethylamino)phenyl, 4-ethoxyphenyl, 3-fluoro-4-methylphenyl, 2,4-dimethylphenyl, 4-(trifluoromethyl)phenyl, 4-(dimethylamino)phenyl, 3-methoxyphenyl, 2-methoxy-4-chloro, or 3-(dimethylamino)phenyl.