Aryl substituted indoles and the use thereof
AssigneePurdue Pharma L.P.
InventorsDonald J. Kyle, Chiyou Ni, Laykea Tafesse, Jiangchao Yao
Life of this patent
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Abstract
The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
Claims22
1-60. (canceled)
A compound of Formula XV:
- or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein
- R10 and R11 are each independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, haloalkoxyalkyl, aminoalkyl, alkylaminoalkyl, and dialkylaminoalkyl;
- and
- R14, R15, R16, and R17 are, each independently, selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, and aminocarbonyl.
(canceled)
A compound of an one of Formula XVII:
- or a pharmaceutically acceptable salt, prodrug, or solvate thereof;
- R14, R15, R16, and R17 are, each independently, selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, halogen, haloalkyl, hydroxyalkyl, hydroxy, nitro, amino, cyano, amide, carboxyalkyl, alkoxyalkyl, ureido, acylamino, thiol, acyloxy, azido, alkoxy, carboxy, and aminocarbonyl.
64-74. (canceled)
76-79. (canceled)
(canceled)
(canceled)
87-91. (canceled)
A compound selected from the group consisting of
- 2-amino-3-[5-(4-phenoxyphenyl)-1H-indol-3-yl]propionamide;
- 2-amino-3-(5-(4-phenoxyphenyl)-1H-indol-3-yl)propan-1-ol;
- 2-amino-3-[6-(4-phenoxyphenyl)-1H-indol-3-yl]propionamide;
- 2-amino-3-[7-(4-phenoxyphenyl)-1H-indol-3-yl]propan-1-ol;
- 2-(1-(2-(diethylamino)ethyl)-5-(4-(4-fluorophenoxy)phenyl)-1H-indol-3-yl)-2-hydroxyacetamide;
- (2S,2'S)-3,3′-(5-(4-(4-fluorophenoxy)phenyl)-1H-indole-1,3-diyl)bis(propane-1,2-diol);
- (S)-3-(1-(2-(diethylamino)ethyl)-5-(4-(4-fluorophenoxy)phenyl)-1H-indol-3-yl)propane-1,2-diol;
- (S)-2-(3-(2,3-dihydroxypropyl)-5-(4-(4-fluorophenoxy)phenyl)-1H-indol-1-yl)acetamide;
- and
- (S)-3-(5-(4-(4-fluorophenoxy)phenyl)-1-(2-hydroxyethyl)-1H-indol-3-yl)propane-1,2-diol;
- or a pharmaceutically acceptable salt, prodrug or solvate thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.