Method of blocking perception of malodor
AssigneeMonell Chemical Senses Center
InventorsJoel Drewery Mainland, Paul Wise
Life of this patent
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Abstract
Methods and compositions for blocking, inhibiting or reducing the perception of malodor by sensory receptors of a mammalian subject comprise an effective amount of a compound of Table I, a derivative thereof or any combination or mixture of such compounds. Methods for screening for such compositions in cell-based assays are provided.
Claims21
A composition for blocking, inhibiting or reducing the perception of malodor by sensory receptors of a mammalian subject comprising an effective amount of a compound of Table I or a derivative thereof in a carrier.
3-6. (canceled)
(canceled)
A method for blocking, inhibiting, counteracting or reducing the perception of malodor by a mammalian subject comprising blocking the TAAR olfactory receptors with a compound of Table I or a derivative thereof.
A method for identifying or screening malodor blocking molecules, compounds or compositions comprises contacting a mammalian cell or cell line that expresses a trace amine-associated receptor (TAAR) protein under in vitro culture conditions with a test molecule or compound;
- and detecting or measuring the expression level or functional activity of the TAAR protein in the contacted cell or cell line in the presence and absence of the test compound or a control.
Dependencies are inferred from the claim text.