Lipid Nanoparticle Compositions and Methods of Making and Methods of Using the Same
AssigneeOhio State Innovation Foundation
InventorRobert J. Lee
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Abstract
Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.
Claims89
A lipid nanoparticle comprising a combination of tertiary and quaternary amine-based cationic lipids, except not, wherein said combination consists of the tertiary amine-cationic lipid present at about 40.0 molar percent;
- wherein the tertiary amine-cationic lipid comprises N-[1-(2, 3-dioleyloyx) propyl]-N—N—N-dimethyl ammonium chloride (DODMA), and the concentration of the quaternary amine-cationic lipid present at about 5.0 molar percent.
A lipid nanoparticle having a diameter of less than 300 nm and comprising a peptide.
A lipid nanoparticle comprising a DNase- or RNase-degrading agent.
A lipid nanoparticle having a diameter of less than 300 nm and comprising a combination of two or more of:
- a mixture of tertiary and quaternary amine-cationic head groups;
- an antibiotic;
- or
- a DNase or RNase-degrading agent.
A lipid nanoparticle comprising, an anti-miR-221 and SPLN-G20, wherein SPLN-G20 comprises:
- DMHDA, DOTAP, GRAM, DOPE and TPGS at a molar ratio of 40:5:20:30:5.
A composition comprising anti-miR-221 combined a lipid nanoparticle.
A composition comprising anti-miR-155 combined with a lipid nanoparticle.
Dependencies are inferred from the claim text.