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US 2018/0021416 A1Published application
Treatment of diseases related to hyperactivity of the complement system
AssigneeCambridge Enterprise Limited
InventorPeter Lachmann
Life of this patent
Estimating the term…
Abstract
Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-inflammatory effects of iC3b. Methods, agents, and compositions for treatment of such diseases are described.
Claims13
1-73. (canceled)
A method of lowering the amount of C3b activity in a subject, the method comprising:
- increasing the level of C3b-inactivating activity and/or iC3b degrading activity in the subject;
- wherein the level of C3b-inactivating activity and/or iC3b degrading activity in the subject is increased to a level that exceeds a normal level of C3b-inactivating activity and/or iC3b degrading activity in the subject.
Dependencies are inferred from the claim text.