Ruthenium and Indium Binding to Gastrins
AssigneeEupharma Pty Ltd
InventorMalvin EUTICK
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Abstract
The present invention relies on the hitherto unrealised high affinity binding of ruthenium and indium to gastrins. Particularly, these metals can be bound directly to the gastrins under mild conditions and so can be used in treatment of conditions associated with elevated gastrin levels and in detection of tumours and other conditions where CCK receptors are over expressed.
Claims32
A method of treatment or prophylaxis of a condition in a patient associated with elevated concentrations of a non-amidated gastrin including the step of administering an effective amount of a metal selected from indium and ruthenium to the patient.
A method of modulating the activity of a non-amidated gastrin including the step of binding a metal selected from indium and ruthenium to the non-amidated gastrin.
A method of treatment or prophylaxis of a condition in a patient associated with over-expression of a CCK receptor including the step of administering an effective amount of a metal selected from indium and ruthenium to the patient.
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A complex comprising a gastrin and a metal selected from indium and ruthenium bound or complexed to the ferric binding site of the gastrin.
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Dependencies are inferred from the claim text.