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US 2018/0021357 A1Published application
Methods for treating bacterial infection
AssigneesBall State Innovation Corporation, Stc.Unm
InventorsSusan A. McDowell, Robert E. Sammelson, Larry A. Sklar, Mark K. Haynes
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.
Claims17
A method of suppressing bacterial infection comprising:
- administering ML 141 or its analogs to cells infected by Staphylococcus,
- where the analogs are defined by the following structures:
- where
- Ar is phenyl, acetamidophenyl (-Ph-NH—CO-Me), or propanamidophenyl (Ph-NH—CO-Et), R is hydrogen, R′ is hydrogen, and Ar′ is methoxyphenyl (-Ph-O-Me), acetamidophenyl (-Ph-NH—CO-Me), or dimethylaminophenyl (Ph-N-Me2);
- and
- where Ar is phenyl and Ar′ is methoxyphenyl (-Ph-O-Me).
3 more elements
A method of suppressing bacterial infection, comprising:
- providing a chemical defined by the following structures:
- where
- Ar is phenyl, acetamidophenyl (-Ph-NH—CO-Me), or propanamidophenyl (Ph-NH—CO-Et), R is hydrogen, R′ is hydrogen, and Ar′ is methoxyphenyl (-Ph-O-Me), acetamidophenyl (-Ph-NH—CO-Me), or dimethylaminophenyl (Ph-N-Me2);
- and
- where Ar is phenyl and Ar′ is methoxyphenyl (-Ph-O-Me);
- and
- providing the chemical to cells infected by Staphylococcus.
4 more elements
A method of suppressing bacterial infection comprising:
- administering ML 141 or its analogs to a patient infected by bacteria of the genus Staphylococcus,
- where the analogs are defined by the following structures:
- where
- Ar is phenyl, acetamidophenyl (-Ph-NH—CO-Me), or propanamidophenyl (Ph-NH—CO-Et), R is hydrogen, R′ is hydrogen, and Ar′ is methoxyphenyl (-Ph-O-Me), acetamidophenyl (-Ph-NH—CO-Me), or dimethylaminophenyl (Ph-N-Me2);
- and
- where Ar is phenyl and Ar′ is methoxyphenyl (-Ph-O-Me).
3 more elements
Dependencies are inferred from the claim text.