Method of Safely and Effectively Treating and Preventing Secondary Hyperparathyroidism in Chronic Kidney Disease
AssigneeOpko Renal, LLC
InventorsCharles W. Bishop, Eric J. Messner
Life of this patent
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Abstract
A method of treating and preventing secondary hyperparathyroidism in CKD by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering 25-hydroxyvitamin D3 with or without 25-hydroxyvitamin D2 and, as necessary, 1,25-dihydroxyvitamin D2 as a Vitamin D hormone replacement therapy.
Claims16
A method of treating and/or preventing secondary hyperparathyroidism in a patient suffering from chronic kidney disease, comprising increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the patient by administering sustained release 25-hydroxyvitamin D3 and optionally 25-hydroxyvitamin D2, wherein 25-hydroxyvitamin D3 is the predominant prohormone in circulation, in a patient receiving one or more medications that increase the catabolism of vitamin D, or phenytoin, or fosphenytoin, or phenobarbital, or carbamazepine, or rifampin, or one or more medications that reduce absorption of vitamin D, or cholestyramine, or colestipol, or orlistat, or a fat substitute, or one or more medications that inhibit activation of vitamin D, or ketoconazole, or one or more medications that decrease calcium absorption, or a corticosteroid, or any combination of the foregoing.
Dependencies are inferred from the claim text.