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US 2018/0021350 A1Published application
Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
AssigneeClarus Therapeutics, Inc.
InventorsRobert E. DUDLEY, Panayiotis P. CONSTANTINIDES
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Abstract
A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
Claims6
An oral pharmaceutical formulation comprising:
- (a) about 23 wt. % or less of a testosterone ester selected from the group consisting of testosterone enanthate, testosterone undecanoate, testosterone cypionate and testosterone palmitate,
- (b) lipophilic surfactant, and
- (c) polyoxyethylene 40 hydrogenated castor oil,
- wherein the weight ratio of the lipophilic surfactant to polyoxyethylene 40 hydrogenated castor oil ranges from 3.8:1 to 4.2:1.
1 more element
Dependencies are inferred from the claim text.