Novel glp-1 receptor modulators

A method of activation, potentiation, modulation or agonism of a glucagon-like peptide 1 receptor comprising contacting the receptor with an effective amount of a compound having one of the following structures, or a pharmaceutically acceptable diastereomer, enantiomer, racemate, salt, hydrate or solvate thereof:

• wherein
• R2 is —NR41R42;
• R3 is alkyl, alkyl substituted with cyano, or —S(O2)(alkyl);
• R41 and R42 taken together with the N atom to which they are attached form a 4-membered heterocyclyl substituted with —COOH;
• and
• R5 is cycloalkyl optionally substituted singly of multiply with halo, alkyl or haloalkyl.

A method of potentiating a glucagon-like peptide 1 receptor comprising contacting the receptor with a compound having one of the following structures, or a pharmaceutically acceptable diastereomer, enantiomer, racemate, salt, hydrate or solvate thereof:

• wherein
• R2 is —NR41R42;
• R3 is alkyl, alkyl substituted with cyano, or —S(O2)(alkyl);
• R41 and R42 taken together with the N atom to which they are attached form a 4-membered heterocyclyl substituted with —COOH;
• and
• R5 is cycloalkyl optionally substituted singly of multiply with halo, alkyl or haloalkyl;
• in the presence of GLP-1(7-36), GLP-1(9-36) and/or oxyntomodulin.

A method of treatment of a malcondition in a patient for which activation, potentiation, modulation or agonism of a glucagon-like peptide 1 receptor is medically indicated, comprising administering an effective amount of the compound having one of the following structures, or a pharmaceutically acceptable diastereomer, enantiomer, racemate, salt, hydrate or solvate thereof:

• wherein
• R2 is —NR41R42;
• R3 is alkyl, alkyl substituted with cyano, or —S(O2)(alkyl);
• R41 and R42 taken together with the N atom to which they are attached form a 4-membered heterocyclyl substituted with —COOH;
• and
• R5 is cycloalkyl optionally substituted singly of multiply with halo, alkyl or haloalkyl;
• to the patient at a frequency and for a duration of time sufficient to provide a beneficial effect to the patient.