Piperidine derivatives as human papilloma virus inhibitors
AssigneeAviragen Therapeutics, Inc.
InventorsMarta BLUMENFELD, Delphine COMPERE, Jean-Michel GAUTHIER
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Abstract
The present disclosure is directed to antiviral compounds directed against the papilloma virus, to pharmaceutical compositions containing them, to their preparation method and synthesis intermediates, as well as to their use for treating or preventing an infection by the papilloma virus. The present method thus provides an efficient way of treating patients that have lesions associated with an infection by the papilloma virus.
Claims28
A method for treating an infection by the HPV 6 or HPV 11 papilloma virus comprising the administration to a patient in need thereof of an efficient quantity of a compound of formula (I):
- as well as their stereoisomers,
- wherein:
- G1 is a bond or a saturated or unsaturated, branched or linear hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups,
- G2 is a
- group, the N(R) moiety being bound to the nitrogen carrying the groups B and AG1, wherein:
- R is hydrogen atom, an alkyl, a haloalkyl group or a radical selected from the group consisting of carbamate, acetyl, dialkylaminomethyl and —CH2—O—CO— Alk,
- G is a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups,
- W is an oxygen, sulfur or NH,
- R1 and R2 are either identical or different, each represent a group selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl, thio, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl, and haloalkyl group,
- R3 is an acid group or a bioisostere of the acid function selected from the group consisting of a tetrazole, phosphonate, phosphonamide, sulfonate and sulfonamide,
- A is an aryl, cycloalkyl, cycloalkenyl group or a heterocycle, each optionally substituted, and
- B is an aryl group or a 6-membered heterocycle, each optionally substituted,
- as well as their pharmaceutically acceptable salts.
A method for treating an infection by the HPV 6 or HPV 11 papilloma virus comprising the administration to a patient in need thereof of an efficient quantity of a compound of formula (I):
- as well as their stereoisomers,
- wherein:
- G1-A represents a phenyl group or a 6-membered heterocycle, each optionally substituted,
- G2 is a
- group, wherein:
- R is a hydrogen atom,
- G is a bond or a saturated or unsaturated, linear or branched hydrocarbon chain comprising 1-4 carbon atoms, optionally substituted with one or two alkyl groups,
- W is an oxygen, sulfur or NH,
- R1 and R2 are either identical or different, each represent a halogen atom or an alkoxyl,
- R3 is an acid group, and
- B is a phenyl, optionally substituted with one or two alkyl groups and/or a heterocycle,
- as well as their pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.